FlexibodyTM Bispecific Platform
The FlexiBodyTM bispecific platform is a rapid and powerful engineering tool to create multifunctional therapeutic antibodies that can simultaneously bind to multiple distinct epitopes on a target or to multiple targets, resulting in multiple signal pathway blocking, tumor immune cell infiltration, receptor clustering and internalization and increased tumor-specific targeting.
The FlexiBodyTM bispecific platform allows for:
- Dual blocking of two drug targets to inhibit two cell signaling pathways
- Bi-paratopic binding to enhance activity against low expression targets
- Enhanced tumor killing by activating T cells and macrophage conversion
Creating innovative molecules using flexible scaffolds addresses disease biology and impacts mechanism of action
FlexiBodyTM Bispecific Platforms
Types of bsAb design
(A) Antibody fusion proteins
(B) Asymmetric design with scFv
(C,D) Antibody with scFv
(E,F) Fc fusion proteins with Trap/VHH
(G) Fc fusion proteins with Fab/Trap
Scaffold screening based on pair compatibility/CMC, MOA, POC validation, and clinical developability.